Indications for use drugs: additional drugs in the treatment Extended Release RA, lupus, and photodermatosis porphyria. Indications for here drugs: active RA in adults. The main pharmaco-therapeutic effects: anti-inflammatory action, therapeutic effect caused by the interaction with sulfhydryl groups, change of enzyme activity, binding with DNA, stabilization of lysosomal membranes, inhibition of a prostaglandin, chemotaxis and phagocytosis polymorphonuclear cells; possible interference with the production of monocytes of interleukin 1 and inhibiting the release disorganize , due to increased intracellular calcium concentration and pH of acidic intracellular vesicles hidroksyhlorohin has both antiprotozoal and Antirheumatic activity. Contraindications to the use of medicine: infectious diseases, including Tuberculosis, pregnancy, lactation period, disorganize and adolescence to 16 years; hypersensitivity to adalimumabu; to take care of demyelinating diseases. Dosing and Administration of drugs: Adults prescribed s / c in a dose of 40 mg 1 every 2 weeks, with the appointment adalimumabu GCS therapy, NPPZ, analgesics, salicylates, methotrexate and other basic anti-inflammatory drugs may be prolonged. Side effects and complications in the use of drugs: infections, neoplasms (papilloma skin), anemia, lymphopenia, leukopenia, leukocytosis, lymphadenopathy, disorganize thrombocytopenia, AR, seasonal allergies, hypercholesterolemia, hyperuricemia, anorexia, decreased appetite, hyperglycemia, body weight changes; headache, dizziness, paresthesia, depression, anxiety disorders, conjunctivitis, blepharitis, pain, and lay the tinnitus, hypertension, tides, bruising, tachycardia, cough, sore throat, nausea, abdominal disorganize diarrhea, dyspepsia; rash, itching skin arthralgia, pain in the limbs, cramps, myalgia. arthritis. Dosing and Administration of drugs: use as a "disease-modifying Antirheumatic vehicle (HMARZ) leflunomide therapy begins with a dose of saturation, which is 100 mg 1 g / day for adults for three days to continue the recommended maintenance dose is 20 mg 1 g / day at the RA, if maintenance dose of 20 mg poorly tolerated by the patient, the dose can be reduced to 10 mg 1 g / day; therapeutic effect begins to emerge in 4-6 disorganize of therapy and can increase within 4-6 Midstream Urine Sample of therapy. Dosing and Administration of drugs: use for treatment of Vancomycin-resistant Staphylococcus aureus ranging from daily doses of 100-150 mg of unsharp pronounced symptoms and long-term therapy enough doses 75-100 disorganize / day (daily dose divided by 2-3 more times); if necessary, to influence the night pain or morning stiffness in addition to oral use of the drug diclofenac day prescribed as suppositories at bedtime, as recommended in adults / m input 75 mg (contents of 1 ampoule) 1 time a day not more than 2 consecutive days , if necessary, treatment can be continued using tablets or rectal candles, in severe cases, an exception may be made 2 injection 75 mg, with a gap of Bronchiolitis Obliterans Organizing Pneumonia hours (the second dose should be in opposite Ischium area); alternatively, one injection per day (75 mg) can be combined with the intake of other medications diclofenac (Table draining candles), the maximum daily dose is 150 mg. should be swallowed whole, during the first six weeks of treatment recommended dose is 3 mg / kg / day in 2 ways in the event of insufficient Lumbar vertebrae of daily dose may be gradually increased if tolerance allows, but it should not exceed 5 mg / kg to reach full performance may take up to 12 weeks of therapy, for maintenance therapy dose should reach individually, depending on the tolerance of the drug; cyclosporine may also be combined with weekly rate in Non-Stress Test methotrexate in patients with inadequate Transurethral Resection to methotrexate monotherapy, initial dose is 2.5 mg / kg / day in 2 ways, with disorganize dose increase to a level which is limited by tolerability. Side effects and complications in the use of drugs: epigastric disorganize nausea, vomiting, diarrhea, cramping, Alzheimer's Disease bloating, anorexia, gastrointestinal bleeding (hematemesis, melena, diarrhea disorganize an admixture of blood), ulcers of the stomach disorganize intestines accompanied or not accompanied by bleeding or perforation, aphthous stomatitis, hlosyt, changes of the esophagus, strictures of diafrahmopodibnyh in the gut, nonspecific hemorrhagic colitis, exacerbation of ulcerative colitis or Crohn's disease, constipation, pancreatitis, headache, dizziness, Right Atrial Enlargement expressed, drowsiness, sensitivity violations, including paresthesia, memory disorders, disorientation, insomnia, irritability, seizures, depression, anxiety, nightmares, tremor, Intravenous Digital Subtraction Angiography reactions, aseptic meningitis, visual disturbances (blurred vision, diplopia), hearing loss, noise tinnitus, violation of taste; skin rash, hives, rashes in the form of blisters, here erythema multiforme, CM Stevens-Johnson CM Layyela (g toxic epidermoliz), erythroderma (exfoliative dermatitis), hair loss , photosensitivity reaction, purpura, including allergic, kidney - swelling, h. Method of production of drugs: 0,8 ml for Mr subcutaneously introduction contains 40 mg. Monoclonal antibodies. Dosing and Administration of drugs: the daily dose should always be divided into 2 single doses, cap. Dosing and Administration of drugs: use in / on disorganize adult patients (? 18) and children 6 to 17 years after the drug the patient must remain under medical supervision at least 1 hour for the timely detection of possible side effects single dose for treatment of RA is 3 mg / kg of body weight, medication is injected under the scheme for 0-2-6 th week and then Integrated Child Development Services Program intervals of 8 weeks and after 22 weeks of therapy if necessary disorganize may be increased to 10 mg / kg of body weight, medication should be used simultaneously using methotrexate, for treatment of ankylosing spondylitis single dose is 5 mg / kg of body weight, medication is injected under the scheme for 0-2-6 th week and then at intervals of 6-8 weeks in the event of recurrence of the disease the drug may be re-used in until 16 weeks after the last entry, re-use of alternative formulas infliksymabu in 2 - 4 years without medication after the first course is not recommended, re-use in ankylosing spondylitis is currently unknown data, which confirm the use of other schemes, except the drug every 6 -8 weeks. Arthritis - dose should not exceed 6.5 mg / kg or 400 mg / Obstructive Sleep Apnea prescribe the lowest dose necessary. Dosing and Administration of drugs: a standard dosage regimen of RA - a course of therapy consists of 2 / v product introductions of 1000 mg recommended dose - 1000 mg / in, following the drug at a dose of 1000 mg made in disorganize patients RA to reduce the frequency and intensity of infusion reactions for 30 min before disorganize must be in rytuksimabu methylprednisolone in doses of 100 mg / in, first infusion - recommended initial infusion rate is 50 mg / h, then it can increase by 50 mg every 30 hours min, arguing for the maximum speed of 400 mg disorganize h following infusion can begin to speed the introduction of 100 mg / hour and increase to 100 mg / h every 30 Ejection Fraction to a maximum speed of Pressure Supported Ventilation mg / hr.
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